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About hydroxocobalamin
2007: A study in 36 people (average age 63) with coronary artery disease found that taking 500 mg of acetyl-L-carnitine plus 200 mg of alpha-lipoic acid twice daily for 8 weeks lowered systolic blood pressure by 9 mmHg in those with coronary artery disease and high blood pressure, which was significant compared to placebo
However, we now know that these long needles are excessive
Deficiency is common in older adults and can lead to cognitive decline and anemia
Additional well-designed human studies are needed to better understand its safety, effectiveness, and potential role in sleep and circadian health
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